Anesthesiology
Perioperative medicine, anesthetic agents, pain, and patient-centered outcomes.
I'm a fourth year medical student interested in anesthesiology with a research interest in the neuro-immune axis. I hope to study the efficacy of currently used anesthetic agents for inflammatory conditions such as postoperative cognitive dysfunction, depressive disorders, and chronic pain.

Gregory Smith, M.S
Fourth Year Medical Student
Research
My work centers on the neuro-immune axis and the way pharmacology, inflammation, and clinical care intersect.
Perioperative medicine, anesthetic agents, pain, and patient-centered outcomes.
Mechanisms connecting inflammation, immune signaling, and nervous-system function.
Drug mechanisms, cellular responses, and translational therapeutic questions.
Questions grounded in patient care, treatment response, and clinical decision-making.
Respiratory disease, environmental exposure, and inflammatory pathophysiology.
Training
A foundation spanning biochemistry, molecular pharmacology, and clinical medicine.
Touro College of Osteopathic Medicine, Harlem Campus
Stony Brook University
Stony Brook University
Florence University of the Arts
Teaching & mentorship
Teaching and mentoring have remained a consistent part of my scientific and medical training.
Teaching Assistant
Touro College of Osteopathic Medicine, Harlem Campus
Teaching Assistant
Touro College of Osteopathic Medicine, Harlem Campus
Teaching Assistant
Stony Brook University
Teaching Assistant
Stony Brook University
Jacobs School of Medicine and Biomedical Sciences
Buffalo NY, 14203
University of Nicosia Medical School
Cyprus Greece, 2408
Renaissance School of Medicine
Stony Brook NY, 11790
2023-2024
MedAchieve Scholars Program
Learn more2023-2024
Physician for Human Rights Interest Group
Summer 2023
Szema & Tsirka Lab & McClain Labs LLC, Smithtown NY, 11787
Selected scholarship
Peer-reviewed work and scholarly contributions spanning anesthesiology, neuroimmunology, oncology, pulmonary medicine, and dermatopathology.
A. Gupta, A. Bielli, G. Smith, S. McClain, R. Promisloff, M. Lee-Wong, R. Kew, N. Zaghloul, M. Ahmed, J. Cozzarin, A. Szema. Mice with targeted deletion of the Vasoactive Intestinal Peptide (VIP) gene have spontaneous pulmonary arterial hypertension exaggerated with hypoxia. In prep
G. Smith, N. Shah, T. Chen, B Agrest, J. Grotticelli, Anesthesia-mediated Neuroinflammatory Sequelae in Post-Operative Cognitive Dysfunction: Mechanisms and Therapeutic Implications. Front. Anesthesiol. 2024
Smith, Gregory T. "Chronic Scratching and Neurodermatitis Hatching." Unusual Diseases with Common Symptoms: A Clinical Casebook. Cham: Springer International Publishing, 2023. 159-163.
Radin DP, Smith G, Moushiaveshi V, Wolf A, Bases R, Tsirka SE. Lucanthone Targets Lysosomes to Perturb Glioma Proliferation, Chemoresistance and Stemness, and Slows Tumor Growth In Vivo. Front Oncol. 2022 Apr 14;12:852940.
Smith GT, Radin DP, Tsirka SE. From protein-protein interactions to immune modulation: Therapeutic prospects of targeting Neuropilin-1 in high-grade glioma. Front Immunol. 2022 Sep 20;13:958620.
Olsen T, Caruana D, Cheslack-Postava K, Szema A, Thieme J, Kiss A, Singh M, Smith G, McClain S, Glotch T, Esposito M, Promisloff R, Ng D, He X, Egeblad M, Kew R, Szema A. Iraq/Afghanistan war lung injury reflects burn pits exposure. Sci Rep. 2022 Aug 29;12(1):14671.
Nirenberg MS, Requena L, Santonja C, Smith GT, McClain SA. Histopathology of persistent long COVID toe: A case report. J Cutan Pathol. 2022 Sep;49(9):791-794.
Daly TJ, Smith GT, McClain SA. Erythema multiforme-like papules after COVID vaccine administration. Dermatol Online J. 2024 Jun 15;30(3).
Smith, Gregory. "Shocking Sex!!!." Unusual Diseases with Common Symptoms: A Clinical Casebook (2018): 227-233.
Presentations
Research presented across national scientific and medical meetings.
Smith, G.T., Caruana, D.L. and Szema, A.M., 2022. Treatment Strategies and Clinical Outcomes Among Patients with Eosinophilic Esophagitis. In C36. HOT TOPICS IN BEHAVIORAL SCIENCES AND HEALTH SERVICES RESEARCH (pp. A4001-A4001). American Thoracic Society.
Caruana DL, Smith G, Huang PH, Szema AM. Utilization of Allergy And Immunology Services among Rescue Workers Exposed to The World Trade Center Disaster. American Thoracic Society 2022 International Conference, San Francisco, CA.
Dennis L. Caruana; Oneib Qadir; Allison L. Szema; Jonathan C. Li; Gregory Smith; Rehana Rasul; David E. Komatsu; Anthony M. Szema. Mechanical Properties Of Bone In Vasoactive Intestinal Peptide Gene Knockout Mice. Orthopaedic Research Society 2022, Tampa, FL
Radin, D.P., Caponegro, M., Smith, G., Moushiaveshi, V., Selwood, D. and Tsirka, S., 2022. Studies on the function of myeloid‐derived Neuropilin‐1 in glioma: a focus on tumor hypoxia. The FASEB Journal, 36.
G. Smith, A. Bielli, A. Wolf, M. Madeira, D. Radin, D.Hendrix, J. Hurowitz, S. McClain, S. Tsirka, Analysis of the Neuropulmonary Axis Following Lunar Regolith Simulant Exposure. NASA Exploration Science Forum & European Lunar Symposium
Tupper, M.A., Smith, G. and Szema, A.M., 2017. Shock, Dyspareunia, Cardiac Arrest After Essure® Implantation Due To Titanium Gel-Coombs Type IV Reaction. In B56. CRITICAL CARE CASE REPORTS: ICU TOXICOLOGY (pp. A3808-A3808). American Thoracic Society.
Smith, G.T., Qadir, O. and Szema, A., 2020. Need for Penicillin Allergy Testing Among Ehlers-Danlos Syndrome Patients. In C38. RARE LUNG DISEASES (pp. A4981-A4981). American Thoracic Society
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